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Furoxone 100mg (Furazolidone)

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Furoxone Furazolidone (fyoor-a-ZOE-li-done) is used to treat bacterial and protozoal (proe-toe-ZOE-al) infections. It works by killing bacteria and protozoa (tiny, one-celled animals). Some protozoa are parasites that can cause many different kinds of infections in the body.



BRAND NAME: Furoxone

GENERIC NAME: Furazolidone Oral

STORAGE: Store between 59 and 86 degrees F (15 to 30 degrees C), away from moisture and light, and out of reach of children and pets.

PREPARATIONS: Tablets 100mg.

MANUFACTURERS: GlaxoSmithKline

AVAILABLE: Furoxone





Uses
Furazolidone Furoxone is used in the treatment of diarrhea or enteritis caused by bacteria. It may also be useful in treating traveler's diarrhea, typhoid fever, cholera and salmonella infections. It is believed to work by crosslinking the DNA of bacteria.

Indications
Furoxone is indicated for the treatment of bacterial or protozoal diarrhea and inflammation of the small intestine.

Dosage
Tablets (100 mg)

Adult Dosage: One 100-mg tablet four times daily.

Dosage for Children: Those 5 years of age or older should receive 25 to 50 mg (1/4 to 1/2 tablet) four times daily.

Overdose
If you suspect overdose, contact your local poison control center or emergency room immediately.

Precautions
Furoxone is contraindicated in people who have hypersensitivity to ingredients in Furoxone, who are on other known Monoamine Oxidase inhibition drugs; however, when indicated they should be prescribed with caution and at a reduced dosage.

Tyramine-containing foods such as broad beans, yeast extracts, strong unpasteurized cheeses, beer, wine, pickled herring, chicken livers, and fermented products are contraindicated.

Indirectly-acting sympathomimetic amines such as those found in nasal decongestants (phenylephrine, ephedrine) and anorectics (amphetamines) are contraindicated.

Likewise, sedatives, antihistamines, tranquilizers, and narcotics should be used in reduced dosages and with caution. Occasionally people on Furoxone have received an Antabuse type reaction to alcohol. Which might have symptoms like: flushing, slight temperature elevation, difficulty breathing, and a sense of constriction within the chest.

The only time doses larger than recommended or in excess of five days are used is when it must be weighed against the possible hazards of a hypertensive crisis. This is usually related to the accumulation of monoamine oxidase inhibitors.

Other Monoamine Oxidase should be taken with caution with Furoxone.

It has been proven that Furoxone can cause tumors in high doses over. If you notice any bothersome symptoms immediately speak to a doctor.

This medicine may cause harm to an unborn baby. Before taking Furoxone, tell your doctor if you are pregnant or plan to become pregnant during treatment. Furoxone passes into breast milk and may causes harm to a nursing baby. Consult your doctor before using this medication if you are pregnant or breast-feeding a baby.

You should consult a doctor before using this medication if you are allergic to Furazolidone or similar medicines, or any of the other ingredients of Furoxone.

Drug Interactions
Consult a doctor before taking Furozone, if you are taking: praclonidine, brimonidine, bethanidine, bupropion, buspirone, carbamazepine, dextromethorphan, entacapone, herbal products (e.g., ma huang), indoramin, meperidine, papaverine, sibutramine, SSRI antidepressants (e.g., fluoxetine, citalopram), sympathomimetics (e.g., methylphenidate, ephedrine), tolcapone, tricyclic antidepressants (e.g., amitriptyline, doxepin), or "triptans" (e.g., sumatriptan, zolmitriptan).

Before using this Furoxone, tell your doctor or pharmacist about all prescription and nonprescription medications, including herbal products, minerals and vitamins or the following products: levodopa, insulin and oral diabetes drugs, other MAO inhibitors (e.g., linezolid, moclobemide, phenelzine, tranylcypromine), sedatives, sleeping pills, drugs used for blood pressure.

Foods to watch out for: foods containing tyramine, include meat or fish (pickled herring/liver/dry sausage/salami/meats prepared with tenderizer), dairy (yogurt/sour cream/aged cheeses - cream or cottage cheese are okay), beverages (beer/red wine/sherry - avoid excessive amounts of caffeine-containing colas/coffee/tea), fruits and vegetables (avocado/bananas/figs/raisins/broad beans/sauerkraut), other (yeast extract/soy sauce/large amounts of chocolate).

SIDE EFFECTS
Headache, stomach upset, nausea, vomiting, dizziness or weakness may occur especially the first several days as your body adjusts to the medication. If any of these effects become bothersome or severe, inform your doctor. Notify your doctor if you develop: a fever, skin rash, itching, muscle aches, flushing, breathing trouble. This medication may cause the urine to turn brown in color. Do not be alarmed. Expect this effect.

If any of these side effects become bothersome seek medical attention immediately. A very serious allergic reaction to this drug is rare. Get emergency medical help if you have any of these signs of an allergic reaction: all in blood pressure, hives, fever, joint pain, and measles looking rash. This may not be a complete list of side effects and may be subject to change, consult with your doctor or pharmacist if you are experiencing any worrisome side effects.

Furazolidone Furoxone and Alcohol
Concurrent use of alcohol and furazolidone may lead to a disulfiram-like reaction (flushing, dyspnea, lacrimation, nausea, sweating). The mechanism may be due to inhibition of aldehyde dehydrogenase by furazolidone, resulting in an accumulation of acetaldehyde.

Patients should be warned of this potential interaction and counseled to avoid alcohol while taking furazolidone or within four days of stopping therapy.


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