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Generic for Chloromycetin 250mg (Chloramphenicol)

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Chloromycetin Chloramphenicol use for bacterial infections caused by salmonella typhi, salmonella species, H. influenzae, meningeal infections, rickettsia, Lymphogranuloma-psittacosis group, different kinds fo gram-negative bacteria causing bacteremia, meningitis, various gram-negative bacteria causing bacteremia, meningitis, mycoplasma, chlamydia, and chlamydophila or other serious gram-negative infections. It can also be used to treat cystic fibrosis regimens.


BRAND NAME: Fencol, Chloromycetin, Econochlor, Fenicol, Kemicetine, Novochlorocap, Sno Phenicol, Anuar, Bioticaps, Farmicetina, Isopto Fenicol, Klonalfenicol, Pluscloran, Poenfenicol, Quemicetina, Chlorsig, Halomycetin, Kemicetin, Oleomycetin, Amplobiotic, Arifenicol, Auridonal, Feniclor, Fenicloran, Neo Fenicol, Sintomicetina, Uni Fenicol, Visalmin, Vixmicina, Pentamycetin, Clorampast, Gemitin, Oftan Akvakol, Oftan Chlora, Cebenicol, Paraxin, Posifenicol C, Thilocanfol C, Thilocof

GENERIC NAME: Chloramphenicol

STORAGE: Store between 20 C to 25 C (68 F to 77 F). Keep out of the reach of children or pets.

PREPARATIONS: Chloramphenicol Tablets: 250 mg, 500 mg

MANUFACTURERS: Ind-Swift, etc

AVAILABLE: Generic for Chloromycetin - Fencol





How Chloromycetin Works
Chloromycetin is an antibiotic, it interferes with the fabrication of proteins that the bacteria need to grow, multiply and divide. By doing so they inhibit the ability of the bacteria to expand, making bacteria static, and therefore preventing the spread of infection.

Chloramphenicol is an alternative in the treatment when tetracyclines cannot be given for rickettsial infections, such as typhus or Rocky Mountain spotted fever.

Chloramphenicol has been used to treat protozoa infections in animals, tick-transmitted diseases in animals, such as Rocky Mountain spotted fever. Chloramphenicol is not effective against infections caused by parasites (intestinal worms), mites, viruses, or fungi.

Chloramphenicol Dosage
Chloramphenicol, like other potent drugs, should be prescribed at recommended doses known to have therapeutic activity. Administration of 50 mg/kg/day in divided doses will produce blood levels of the magnitude to which the majority of susceptible microorganisms will respond.

As soon as feasible an oral dosage form of another appropriate antibiotic should be substituted for intravenous chloramphenicol sodium succinate.

The following method of administration is recommended:

Intravenously as a 10% (100 mg/mL) solution to be injected over at least a one-minute interval. This is prepared by the addition of 10 mL of an aqueous diluent such as water for injection or 5% dextrose injection.

Adults
Adults should receive 50 mg/kg/day in divided doses at 6-hour intervals. In exceptional cases patients with infections due to moderately resistant organisms may require increased dosage up to 100 mg/kg/day to achieve blood levels inhibiting the pathogen, but these high doses should be decreased as soon as possible. Adults with impairment of hepatic or renal function or both may have reduced ability to metabolize and excrete the drug. In instances of impaired metabolic processes, dosages should be adjusted accordingly. (See discussion under Neonates.) Precise control of concentration of the drug in the blood should be carefully followed in patients with impaired metabolic processes by the available microtechniques (information available on request).

Pediatric Patients
Dosage of 50 mg/kg/day divided into 4 doses at 6-hour intervals yields blood levels in the range effective against most susceptible organisms. Severe infections (eg, bacteremia or meningitis), especially when adequate cerebrospinal fluid concentrations are desired, may require dosage up to 100 mg/kg/day; however, it is recommended that dosage be reduced to 50 mg/kg/day as soon as possible. Children with impaired liver or kidney function may retain excessive amounts of the drug.

Overdose
The symptoms of overdose are as follows: nausea, vomiting, rashes, and severe allergic reaction. If you have any of the signs of allergic reaction get in contact with your local emergency room or poison control center.

Possible side effects of Chloramphenicol
The most serious adverse effect in people is an irreversible suppression of the blood-forming cells (aplastic anemia). For this reason, chloramphenicol exposure in humans should be limited as much as possible.

This reaction (aplastic anemia) is not possible in animals, however chloramphenicol may suppress the blood-forming cells in a reversible manner if administered for prolonged periods at high doses. In cats, for example, this reaction may be observed after two weeks of continuous treatment.

Do not administer chloramphenicol to pregnant animals or very young animals.

Chloramphenicol may interact with other medications. Cats are most susceptible to adverse reactions from chloramphenicol. Vomiting, lack of appetite and diarrhea are possible from chloramphenicol.

This is not a complete list and adverse side effects may be subject to change. If you are currently on this medication and you experience any bothersome side effects please consult a doctor.

Precautions
Always consult a doctor before taking this medication; some serious reactions have been seen in some patients even during short-term therapy. Before taking this medication tell your doctor about any other prescription or non prescription drugs you may be taking, including vitamins and supplements. Also be sure to tell your doctor about any know allergic reactions you may have to this medicine or any of its other ingredients.

Chloromycetin is contraindicated if a stronger antibiotic can be used instead. People with a history of previous hypersensitivity or toxic reaction to it should not use this medication.

Pregnant woman or woman who might become pregnant should not use this medication. Talk to your doctor about alternatives. There is no clear evidence of fetal risk however all expecting mothers should consult a physician before taking this medication. Gray baby syndrome is a concern when taking this antibiotic.

Difficile associated with diarrhea has been reported with all antibacterial agents. It may range form mild diarrhea to fatal colitis. Repeated courses of chloramphenicol treatment should be avoided if possible. Excessive blood levels may result from use especially in cases of impaired liver or kidney function.

The use of antibiotics with other types of antibiotics may cause the overgrowth of nonsuceptible organisms, including fungi. If this should happen during therapy then measures should be taken by a doctor.

Some serious reactions have happen on people using Chloromycin, even during short-term use, these symptoms include: blood dyscrasias such as aplastic anemia, hypoplastic anemia, thrombocytopenia (low platelet count) and granulocytopenia (low concentration of granulocytes in the blood).

It is very important that hematologic studies be conducted before chloramphenicol therapy. As aforementioned any dangerous reactions should be cause to discontinue therapy.

Chloromycetin Chloramphenicol and Alcohol
Because both chloramphenicol and alcohol have been demonstrated to cause anemia, reduced bone marrow production and other negative side effects, consuming alcohol while taking chloramphenicol increases the risk of developing these conditions. Both substances lower the immune response and damage some of the same mechanisms in the human body.


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