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Generic for Dexone 0.5mg (Dexamethasone Oral)

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Dexone (Dexamethasone) is a corticosteroid, is similar to a natural hormone produced by the adrenal glands and is used to treat arthritis, skin, blood, kidney, eye, thyroid, intestinal disorders, severe allergies, and asthma. Dexone is also used to treat certain types of cancer and occasionally, cerebral edema. Dexone is available as a generic termed dexamethasone; however the brand name Dexone is no longer available in the U.S. Side effects of Dexone may include GI symptoms (nausea, vomiting), headache, acne or skin rash, increased hair growth, irregular menstrual periods, easy bruising, and anxiety, or depression.


BRAND NAME: Decadron, Dexasone, Diodex, Hexadrol, Maxidex, Dexone

GENERIC NAME: Dexamethasone

STORAGE: Dexamethasone should be stored at 68 - 77F (20 - 25C) and not frozen. Keep this medication in the container it came in, tightly closed, and out of reach of children.

PREPARATIONS: Tablets: 0.25mg, 0.5mg, 0.75mg, 1mg, 1.5mg, 2mg, 4mg, and 6mg. Elixir: 0.5 mg /5 mL. Solution: 0.5, 1 mg/5 ml

MANUFACTURERS: Zydus, etc

AVAILABLE: Generic for Dexone - Dexona





What is Dexamethasone
Dexamethasone is a member of the glucocorticoid class of hormones. This means they are steroids but, unlike the anabolic steroids that we hear about regarding sports medicine, these are "catabolic" steroids. Instead of building the body up, they are designed to break down stored resources (fats, sugars and proteins) so that they may be used as fuels in times of stress. Cortisone would be an example of a related hormone with which most people are familiar, though cortisone (more correctly called "cortisol") is a natural hormone produced by the body's adrenal glands whereas dexamethasone is synthetic.

In most cases, we do not use glucocorticoids for their influences on glucose and protein metabolism; we use them because in higher doses they are broadly anti-inflammatory. Their uses fit into several groups:

- Anti-inflammatory (especially for joint pain and itchy skin).

- Immune-suppression (treatment of conditions where the immune system is destructively hyperactive. Higher doses are required to actually suppress the immune system).

- Cancer Chemotherapy (especially in the treatment of lymphoma).

- Central Nervous System Disorders (usually after trauma or after a disc episode to relieve swelling in the brain or spinal cord).

-Shock (steroids seem to help improve circulation though this use is somewhat controversial).

- Blood Calcium Reduction (in medical conditions where blood calcium is dangerously high treatment is needed to reduce levels to normal).

Why is Dexamethasone prescribed?
Dexamethasone, a corticosteroid, is similar to a natural hormone produced by your adrenal glands. It often is used to replace this chemical when your body does not make enough of it. It relieves inflammation (swelling, heat, redness, and pain) and is used to treat certain forms of arthritis; skin, blood, kidney, eye, thyroid, and intestinal disorders (e.g., colitis); severe allergies; and asthma. Dexamethasone is also used to treat certain types of cancer.

This medication is sometimes prescribed for other uses; ask your doctor or pharmacist for more information.

Dosing
Dosage requirements of corticosteroids vary greatly among individuals and the diseases being treated. In general, the lowest possible effective dose is used. The initial oral dose is 0.75 to 9 mg daily depending on the disease. The initial dose should be adjusted based on response. Corticosteroids given in multiple doses throughout the day are more effective but also are more toxic as compared with the same total daily dose given once daily, or every other day.

What side effects can this medication cause?
Dexamethasone is commonly used for several weeks or even months at a time to get a chronic process under control. It is important that the dose be tapered to an every third day schedule once the condition is controlled. The reason for this is that body will perceive the presence of these hormones and not produce any of its own. In time, the adrenal glands will atrophy so that when the medication is discontinued, the patient will be unable to respond to any stressful situation. An actual circulatory crisis can result. By using the medication every other day, this allows the body's own adrenal glands to remain active.

Dexamethasone may cause side effects. Tell your doctor if any of these symptoms are severe or do not go away:

- upset stomach
- stomach irritation
- vomiting
- headache
- dizziness
- insomnia
- restlessness
- depression
- anxiety
- acne
- increased hair growth
- easy bruising
- irregular or absent menstrual periods

If you experience any of the following symptoms, call your doctor immediately:

- skin rash
- swollen face, lower legs, or ankles
- vision problems
- cold or infection that lasts a long time
- muscle weakness
- black or tarry stool

INTERACTIONS WITH OTHER DRUGS
Glucocorticoid hormones should not be used in combination with medications of the NSAID class (ie aspirin, carprofen, meloxicam etc.) as the combination of these medications could lead to bleeding in the stomach or intestine. Ulceration could occur.

Dexamethasone Dexone and Alcohol
Dexamethasone and alcohol can cause stomach ulcers. Do not take alcohol with Dexone.


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