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Generic for Furadantin 50mg 100mg (Nitrofurantoin)

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Nitrofurantoin Furadantin is an antibiotic which is used to treat and prevent urinary tract infections. The mechanism by which nitrofurantoin kills bacteria is unknown. However it is well absorbed from the gut and reaches high concentrations in the urine where it kills the bacteria responsible for these infections.



BRAND NAME: Macrodantin, Furadantin, Macrobid, Niftran, Martifur

GENERIC NAME: Nitrofurantoin

STORAGE: All formulations should be kept at room temperature, 15-30C (59-86F).

PREPARATIONS: Capsules: 25mg, 50mg, 75mg, and 100mg. Oral suspension: 25mg/5ml.

MANUFACTURERS: Martin & Harris, Ranbaxy, etc

AVAILABLE: Generic for Furadantin - Niftran, Martifur





Uses For Furadantin
Furadantin (nitrofurantoin), a synthetic chemical, is a stable, yellow, crystalline compound. Nitrofurantoin is used to treat urinary tract infections. This medicine is an antibiotic. It works by killing bacteria or preventing their growth. However, this medicine will not work for colds, flu, or other virus infections.

Inactive Ingredients: Furadantin Oral Suspension contains carboxymethylcellulose sodium, citric acid, flavors, glycerin, magnesium aluminum silicate, methylparaben, propylparaben, purified water, saccharin, sodium citrate, and sorbitol.

CONTRAINDICATIONS
Anuria, oliguria, or significant impairment of renal function (creatinine clearance under 60 mL per minute or clinically significant elevated serum creatinine) are contraindications. Treatment of this type of patient carries an increased risk of toxicity because of impaired excretion of the drug.

Because of the possibility of hemolytic anemia due to immature erythrocyte enzyme systems (glutathione instability), the drug is contraindicated in pregnant patients at term (38-42 weeks gestation), during labor and delivery, or when the onset of labor is imminent. For the same reason, the drug is contraindicated in neonates under one month of age.

Furadantin is also contraindicated in those patients with known hypersensitivity to nitrofurantoin.

Before Using Furadantin
In deciding to use a medicine, the risks of taking the medicine must be weighed against the good it will do. This is a decision you and your doctor will make. For this medicine, the following should be considered:

Allergies. Tell your doctor if you have ever had any unusual or allergic reaction to this medicine or any other medicines. Also tell your health care professional if you have any other types of allergies, such as to foods, dyes, preservatives, or animals. For non-prescription products, read the label or package ingredients carefully.

Pediatric. Appropriate studies performed to date have not demonstrated pediatric-specific problems that would limit the usefulness of nitrofurantoin in children. Safety and efficacy have not been established in infants below 1 month of age.

Geriatric. Appropriate studies performed to date have not demonstrated geriatric-specific problems that would limit the usefulness of nitrofurantoin in the elderly. However, elderly patients are more likely to have age-related heart, liver, lung, or kidney problems, which may require caution in patients receiving nitrofurantoin.

Breast Feeding. Studies in women suggest that this medication poses minimal risk to the infant when used during breastfeeding.

Interactions with Medicines
Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. In these cases, your doctor may want to change the dose, or other precautions may be necessary. When you are taking this medicine, it is especially important that your healthcare professional know if you are taking any of the medicines listed below. The following interactions have been selected on the basis of their potential significance and are not necessarily all-inclusive.

Using this medicine with any of the following medicines is usually not recommended, but may be required in some cases. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.

- Fluconazole

Dosing
The dose of this medicine will be different for different patients. Follow your doctor's orders or the directions on the label. The following information includes only the average doses of this medicine. If your dose is different, do not change it unless your doctor tells you to do so.

The amount of medicine that you take depends on the strength of the medicine. Also, the number of doses you take each day, the time allowed between doses, and the length of time you take the medicine depend on the medical problem for which you are using the medicine.

For oral dosage forms (capsules, suspension, and tablets):
For prevention of urinary tract infections: - Adults and teenagers - 50mg to 100 milligrams (mg) at bedtime. - Children and infants 1 month of age and older - Dose is based on body weight and must be determined by your doctor. - Infants younger than 1 month of age—Use is not recommended.

For treatment of urinary tract infections:
- Adults and teenagers - 50mg to 100 milligrams (mg) every six hours. - Children and infants 1 month of age and older - Dose is based on body weight and must be determined by your doctor. - Infants younger than 1 month of age - Use is not recommended.

For oral dosage form (extended-release capsules):
For treatment of urinary tract infections: - Adults, teenagers, and children 12 years of age and older - 100 milligrams (mg) every twelve hours for seven days. - Children younger than 12 years of age - Use and dose must be determined by your doctor.

Missed Dose
If you miss a dose of this medicine, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not double doses.

OVERDOSAGE
Occasional incidents of acute overdosage of Furadantin (nitrofurantoin) have not resulted in any specific symptoms other than vomiting. Induction of emesis is recommended. There is no specific antidote, but a high fluid intake should be maintained to promote urinary excretion of the dug. It is dialyzable.

SIDE-EFFECTS AND SPECIAL PRECAUTIONS
Gastrointestinal Reactions:
Anorexia, nausea and emesis are the most frequent reactions; abdominal pain and diarrhoea occur less frequently. These dose-related toxicity reactions can be minimised by reduction of dosage, especially in the female patient. Hepatitis occurs rarely.

Hypersensitivity Reactions:
Pulmonary sensitivity reactions may occur, which can be acute, subacute or chronic.

Acute reactions are commonly manifested by fever, chills cough chest pain, dyspnoea, pulmonary infiltration with consolidated or pleural effusion on X-ray, and eosinophilia. The acute reactions usually occur within the first week of treatment and are reversible with cessation of therapy. Resolution may be dramatic.

In subacute reactions, fever, and eosinophilia are observed less often. Recovery is somewhat slower, perhaps as long as several months. If the symptoms are not recognised as being drug related and nitrofurantoin is not withdrawn, symptoms may become more severe.

Chronic pulmonary reactions are more likely to occur in patients who have been on continuous nitrofurantoin therapy for six months or longer. The insidious onset of malaise, dyspnoea on exertion, cough and altered pulmonary function are common manifestations. Rontgenographic and histologic findings of diffuse interstitial pneumonitis or fibrosis, or both, are also common manifestations. Fever is rarely prominent.

The severity of these chronic pulmonary reactions and the degree of their resolution appear to be related to the duration of therapy after the first clinical signs appear. Pulmonary function may be permanently impaired even after cessation of nitrofurantoin therapy. This risk is greater when pulmonary reactions are not recognised early.

Dermatologic Reactions:
Maculopapular, erythematous, or eczematous eruption, pruritus, urticaria and angioedema.

Other Sensitivity Reactions:
Anaphylaxis, asthmatic attack in patients with history of asthma, cholestatic jaundice, drug fever and arthralgia.

Haematologic Reactions:
Haemolytic anaemia, granulocytopenia, leucopenia, eosinophilia, and megaloblastic anaemia. Return of the blood picture to normal has followed cessation of therapy.

Neurological Reactions:
Peripheral neuropathy, headache, dizziness, nystagmus and drowsiness.

Miscellaneous Reactions:
Transient alopecia. As with other antimicrobial agents, superinfections by resistant organisms may occur. With "Furadantin", however, these are limited to the genito-urinary tract because suppression of normal bacterial flora elsewhere in the body does not occur.

Nitrofurantoin Furadantin and Alcohol
If you have the side effects of GIT upset and/or nausea because of the antibiotics, these symptoms might be worsened by alcohol. Alcohol will not decrease the activity of the drug but might induce some unwanted side effects.


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